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2-PHENYLINDOLIZINE

  • Name: 2-PHENYLINDOLIZINE
  • CAS: 25379-20-8
  • Purity: 99%
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  • Description

    Good factory exports good 2-PHENYLINDOLIZINE 25379-20-8

    • Molecular Formula: C14H11N
    • Molecular Weight: 193.248
    • Appearance/Colour: white to beige fine crystalline powder 
    • Melting Point: 211-214 °C 
    • Refractive Index: 1.608 
    • Boiling Point: 319.47°C (rough estimate) 
    • PSA： 4.41000 
    • Density: 1.05 g/cm3 
    • LogP: 3.60630 

    2-PHENYLINDOLIZINE(Cas 25379-20-8) Usage

    Purification Methods

    Crystallise 2-pKEst phenylindolizine from EtOH. The 0.25HCl crystallises from MeCN with m 109o, and the picrate has m 161o when crystallised from EtOAc. [Beilstein 20 II 304, 20 III/IV 4033, 20/8 V 244.]

    InChI:InChI=1/C14H11N/c1-2-6-12(7-3-1)13-10-14-8-4-5-9-15(14)11-13/h1-11H

    25379-20-8 Relevant articles

    Dithiolation indolizine exerts viability suppression effects on A549 cells via triggering intrinsic apoptotic pathways and inducing G2/M phase arrest

    Li, Guanting,Wu, Xianwei,Sun, Peng,Zhang, Zhiyang,Shao, Enxian,Mao, Jianping,Cao, Hua,Huang, Hongliang

    , (2021)

    Indolizine derivatives have been reporte...

    Electrochemical diselenylation of indolizines: Via intermolecular C-Se formation with 2-methylpyridines, α-bromoketones and diselenides

    Li, Junxuan,Liu, Xiang,Deng, Jiadi,Huang, Yingshan,Pan, Zihao,Yu, Yue,Cao, Hua

    , p. 735 - 738 (2020)

    An efficient electrochemical system for ...

    Photocatalytic Synthesis of 3-Sulfanyl- and 1,3-Bis(sulfanyl)indolizines Mediated by Visible Light

    Gomes, Caroline S.,Lenard?o, Eder J.,Monzon, Loana I.,Penteado, Filipe,Perin, Gelson,Silveira, Claudio C.

    , (2020)

    A metal-free method for the synthesis of...

    Transition-Metal-Free Regioselective Cross-Coupling: Controlled Synthesis of Mono- or Dithiolation Indolizines

    Li, Bin,Chen, Zhiyu,Cao, Hua,Zhao, Hong

    , p. 3291 - 3295 (2018)

    An efficient transition-metal-free regio...

    Oxidation Potential-Guided Electrochemical Radical-Radical Cross-Coupling Approaches to 3-Sulfonylated Imidazopyridines and Indolizines

    Kim, Wansoo,Kim, Hun Young,Oh, Kyungsoo

    , p. 15973 - 15991 (2021/07/26)

    Oxidation potential-guided electrochemic...

    Mechanochemical Synthesis of 1,2-Diketoindolizine Derivatives from Indolizines and Epoxides Using Piezoelectric Materials

    Wang, Yumei,Zhang, Ziwu,Deng, Lichan,Lao, Tianfeng,Su, Zhengquan,Yu, Yue,Cao, Hua

    supporting information, p. 7171 - 7176 (2021/09/14)

    A simple and efficient mechanochemical-i...

    Regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions

    Cao, Hua,Lin, Jiatong,Liu, Xiang,Song, Dan,Zhan, Haiying,Zhang, Zemin,Zhuang, Canzhan

    supporting information, p. 5284 - 5288 (2021/06/28)

    An efficient and straightforward metal-f...

    25379-20-8 Process route

    2-methyl-1-(2-oxo-2-phenylethyl)pyridinium bromide
    32896-98-3

    2-methyl-1-(2-oxo-2-phenylethyl)pyridinium bromide

    2-phenylindolizine
    25379-20-8

    2-phenylindolizine

    Conditions
    Conditions Yield
    With N,N-dimethyl-formamide dimethyl acetal; In N,N-dimethyl-formamide; for 0.166667h; Heating;
    		97%
    With potassium hydroxide; In water; at 70 ℃; for 0.5h;
    		84%
    With sodium hydrogencarbonate; In water; for 0.333333h; Heating;
    		80%
    With potassium hydrogencarbonate; In water; for 1h; Heating;
    		76.8%
    With sodium hydrogencarbonate; In water; for 0.166667h; Heating;
    		72%
    With sodium hydrogencarbonate; In water; for 0.5h; Heating / reflux;
    		70%
    With sodium hydrogencarbonate; In water; for 0.5h; Heating / reflux;
    		70%
    With water; sodium hydrogencarbonate;
    With potassium carbonate; In water; at 80 ℃;
    		2.51 g
    With potassium carbonate; In water; at 60 ℃; for 5h;
    		965 mg
    α-picoline
    109-06-8

    α-picoline

    Cinnamic acid
    621-82-9

    Cinnamic acid

    2-phenylindolizine
    25379-20-8

    2-phenylindolizine

    Conditions
    Conditions Yield
    With 1,10-Phenanthroline; lithium acetate; copper diacetate; nickel; In N,N-dimethyl-formamide; at 140 ℃; for 36h; Inert atmosphere;
    		45%

    25379-20-8 Upstream products

    • 60-29-7
      60-29-7

      diethyl ether

    • 38320-58-0
      38320-58-0

      1-(2-phenyl-indolizin-3-yl)-ethanone

    • 925-90-6
      925-90-6

      ethylmagnesium bromide

    • 14759-45-6
      14759-45-6

      3-benzoyl-2-phenylindolizine

    25379-20-8 Downstream products

    • 38320-58-0
      38320-58-0

      1-(2-phenyl-indolizin-3-yl)-ethanone

    • 14759-45-6
      14759-45-6

      3-benzoyl-2-phenylindolizine

    • 189569-42-4
      189569-42-4

      1,3-diacetyl-2-phenylindolizine

    • 54149-11-0
      54149-11-0

      2-(4-nitrophenyl)indolizine

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